Oct 11 2017
Atezolizumab in Combination with Bevacizumab in Untreated mRCC: Updated Analysis of IMmotion150 Study [LBA39]
Powles T, et al.
The efficacy and safety of atezolizumab (anti-PD-L1) + bevacizumab (anti-VEGF) compared to sunitinib (TKI) in first-line (1L) metastatic renal-cell carcinoma (mRCC) were studied in the open-label, randomized, phase II IMmotion150 study (NCT01984242). Primary analysis (median follow-up, 20.7 mo) was previously reported at ASCO GU 2017. Updated analysis (median follow-up, 25.7 mo) has just been presented at ESMO 2017.
This updated analysis showed clinically meaningful benefit in PFS with atezolizumab + bevacizumab vs. sunitinib in both PD-L1+ and ITT patients. No new safety signals were detected with this updated analysis.
Data showing investigator (INV)-assessed PFS in both PD-L1+ and ITT patients are summarized as below:
These data supported the combination use of atezolizumab (anti-PD-L1) + bevacizumab (anti-VEGF) in 1L mRCC. Clinical benefit of this combination did not come at the expense of increased symptom burden. This combination will be further evaluated in the ongoing phase III IMmotion151 study (NCT02520821).
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