Elaine’s group discovered a cardiac glycoside restrains EGFR-related and EGFR-independent NSCLC cell proliferation with distinct treatment mechanism
Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer and is characterized by the highest mortality and incidence rates among these types of malignancies (1, 2). Traditional Chinese medicine (TCM) has been applied for centuries in China (3, 4). Cardiac glycosides, a class of natural products, have been identified as a potential type of chemotherapeutic agent (5, 6).
Lung Cancer Treatment Seminar
Seminar on lung cancer treatment update was held in Crown Plaza Hotel Macau. The featured speakers included Dr. Tongyu Lin and Dr. Cheng Huang.
Gossypol inhibits non-small cell lung cancer cells proliferation by targeting EGFRL858R/T790M
Dr Elaine Lai Han Leunget al reported thatGossypol inhibits non-small cell lung cancer cells proliferation by targeting EGFRL858R/T790M
Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation
Dr. Elaine LaiHan Leunget al reported that Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation