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劑量

組別	藥物名稱	劑量	途徑	頻率	時間及備註
1	NS	20 mL	IV	D1, D8, D15	速度見備注
	Bleomycin	30 mg
2	NS	250 mL	IVDRIP	D1-D5	速度見備注
	Cisplatin	20 mg/M²
3	NS	500 mL	IVDRIP	D1-D5	速度見備注
	Etoposide	100 mg/M²

Bleomycin dose equivalence: 1,500 International Units is equivalent to 1.5 USP units and approximately equivalent to 1.5mg (by potency) or 1mg (by weight)

Frequency: 21 Days

Cycle: 3 cycles (4 cycles for high risk patients)

預後評分

Good Prognosis	Seminoma	Non-semninoma
Good prognosis	Any primary site and No non-pulmonary visceral metastases and Normal AFP, any ßhCG, any LDH 56% of non-seminoma 5-year PFS 90% 5-year OS 96%	esticular or retroperitoneal primary tumour and No non-pulmonary visceral metastases and Post-orchiectomy markers - all of: AFP less than 1000 microgram/L ßhCG less than 5000 International units/L LDH less than 2.5 x upper limit of norma *0% of seminoma* 5-year *PFS 89%* 5-year OS 95%
Intermediate prognosis	Any primary site and Non-pulmonary visceral metastases and Normal AFP, any ßhCG, any LDH 10% of seminoma 5-year PFS 79% 5-year OS 72%	Testicular or retroperitoneal primary tumour and No non-pulmonary visceral metastases and Post-orchiectomy markers - any of: AFP 1000 to 10 000 microgram/L ßhCG 5000 to 50 000 International units/L LDH 1.5 to 10 x upper limit of normal 28% of non-seminoma 5-year PFS 78% 5-year OS 89%
Poor prognosis	No patients classified as poor prognosis	Mediastinal primary tumour or Non-pulmonary visceral metastases or Post-orchiectomy markers - any of: AFP greater than 10 000 microgram/L ßhCG greater than 50 000 International units/L LDH greater than 10 x upper limit of normal 16% of non-seminoma 5-year PFS 54% 5-year OS 67%

給藥順序和速度

Bleomycin:

Administer bleomycin (irritant):

over 10 minutes, flush with ~ 50 mL of sodium chloride 0.9%

Observe for hypersensitivity reaction especially during the first and second doses

Yypersensitivity reaction can occur with any dose of bleomycin regardless of whether a test dose has been administered.

Cisplatin:

Administer cisplatin (irritant):

via IV infusion over 60 minutes, flush with 100 mL of sodium chloride 0.9%, observe for hypersensitivity reactions which can increase with the number of cycles administered and when given with concomitant radiation therapy.

Infusion-related reaction (IRR):

Stop infusion at first sign of anaphylaxis or severe IRR and manage as per emergency.

Etoposide:

Administer etoposide (irritant):

via IV infusion over 30 to 60 minutes

flush with ~ 100 mL sodium chloride 0.9%.

Infusion-related reaction (IRR)

Stop infusion at first sign of anaphylaxis or severe IRR and manage as per emergency.

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Phone Number

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Dr George Abdreas Pompeia

Medical Oncology