Elaine’s group discovered a cardiac glycoside restrains EGFR-related and EGFR-independent NSCLC cell proliferation with distinct treatment mechanism
Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer and is characterized by the highest mortality and incidence rates among these types of malignancies (1, 2). Traditional Chinese medicine (TCM) has been applied for centuries in China (3, 4). Cardiac glycosides, a class of natural products, have been identified as a potential type of chemotherapeutic agent (5, 6).
Gossypol inhibits non-small cell lung cancer cells proliferation by targeting EGFRL858R/T790M
Dr Elaine Lai Han Leunget al reported thatGossypol inhibits non-small cell lung cancer cells proliferation by targeting EGFRL858R/T790M
Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation
Dr. Elaine LaiHan Leunget al reported that Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation
Novel Direct AMPK Activator Suppresses Non-Small Cell Lung Cancer through Inhibition of Lipid Metabolism
Dr Elaine Lai-Han Leung et al reported that a new AMPK agonist can specifically supress non-small cell lung cancer resistant cells viability by inhibition of lipid metabolism.
Inhibition of KRAS-dependent Lung Cancer Cell Growth by Deltarasin
Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity
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